HNF1A
HNF1A
Overview
HNF1A (hepatocyte nuclear factor 1 alpha) is a transcription factor of major biomedical importance, best known for its role in regulating gene expression in metabolic tissues and for its association with monogenic diabetes, particularly HNF1A-MODY (maturity-onset diabetes of the young). As a protein target, HNF1A is clinically relevant because variation in its function can alter pancreatic beta-cell and hepatic transcriptional programs, contributing to inherited dysglycemia and informing diagnostic classification of diabetes subtypes.
In the recent literature provided here, HNF1A appears primarily in the context of diabetes risk assessment rather than as a direct mechanistic focus in immunology. One study specifically addressed the development of a calculator for estimating the probability of HNF1A-MODY in Asian Indians using clinical and biochemical criteria. This underscores HNF1A’s continuing significance as a diagnostic and stratification marker in precision medicine for diabetes.
Recent Publications Focus
Below is a summary of the newest research publications targeting HNF1A (sorted by publication date).
Recent work has highlighted HNF1A in the context of colorectal cancer liver metastases treated with anti-EGFR-based conversion chemotherapy. In a retrospective single-center study using targeted next-generation resequencing of pre- and post-therapy samples, HNF1A was among the recurrently mutated genes observed in tumors from patients exposed to anti-EGFR monoclonal antibodies plus chemotherapy. The study reported a higher frequency of potential anti-EGFR resistance-associated mutations in post-treatment samples, including HNF1A alterations, but these subclonal resistance mutations did not affect secondary resectability of the liver metastases.
Another recent publication focused on HNF1A in the setting of diabetes genetics rather than cancer. Investigators developed a calculator to estimate the probability of HNF1A-MODY, as well as HNF4A-MODY, in Asian Indians using clinical and biochemical criteria. This work was aimed at improving identification of individuals likely to have monogenic diabetes and supporting more targeted diagnostic evaluation.
Across the broader recent literature, HNF1A appears mainly as a recurrently altered target in tumor sequencing studies rather than as the primary mechanistic focus of functional experiments. In the colorectal liver metastasis study, its enrichment among post-treatment samples suggests a possible role in therapy-associated clonal evolution and resistance profiling, but the abstract does not provide direct functional validation of HNF1A in resistance biology.
Result PMIDs
- [PMID 42012954]
Target PMIDs
- [PMID 41871534]
- [PMID 41891923]
- [PMID 41946709]
- [PMID 42061400]
- [PMID 42156357]
- [PMID 42361199]
- [PMID 42383354]
- [PMID 42406708]