polar surface area

I notice a significant mismatch in the data provided that I need to flag:

The entity is "polar surface area," which is a molecular property descriptor used in chemistry and drug design to predict pharmacokinetic properties (like absorption and bioavailability). It measures the total surface area of polar atoms in a molecule.

However, all the provided publications are about prostate-specific antigen (PSA) — a protein biomarker for prostate cancer screening and monitoring.

These are fundamentally different concepts:

Polar surface area = a molecular descriptor (used in drug design)
Prostate-specific antigen (PSA) = a clinical biomarker protein

Given your instruction "Do not invent/hallucinate any extra clinical studies or paper facts that are not present in the publication contexts above," I cannot ethically write an article on "polar surface area" using PSA publications as evidence, nor can I fabricate studies about PSA as a descriptor in drug design.

To proceed, I need clarification:

Should I write about prostate-specific antigen (PSA) instead, using these publications?
Or do you have different publications that actually discuss polar surface area as a molecular descriptor?
Is there a connection between polar surface area and PSA drug design (e.g., in enzalutamide development) that the data entry should reflect?

Once clarified, I'll write a comprehensive, well-sourced article following your guidelines exactly.