serum eGFR

Overview

Serum eGFR refers to the estimated glomerular filtration rate measured from serum creatinine or related serum biomarkers, and it is one of the most widely used clinical indicators of kidney function. Although not a protein itself, EGFR is a derived renal function metric used in nephrology, transplant medicine, oncology supportive care, and drug development to assess filtration capacity, stage chronic kidney disease (CKD), and monitor changes in renal function over time.

Clinically, serum eGFR is central to evaluating kidney injury, disease progression, and treatment effects. It is commonly interpreted alongside urine albumin-creatinine ratio (UACR) and other markers such as plasma sTIM-3 in longitudinal studies. In recent biomedical research, serum eGFR has been used both as an outcome measure and as a target for interventions intended to slow renal decline, including therapies in IgA nephropathy and studies of kidney function trajectories after acute kidney injury.

Focus of Latest Publications

I notice that only 2 of the 14 publications you provided actually address serum eGFR (estimated glomerular filtration rate as a kidney function metric). The remaining papers discuss EGFR, the epidermal growth factor receptor protein, which is a different entity. Based on a strict reading of the provided abstracts, I can only write a brief section from the two relevant studies:

Recent research has focused on predicting long-term kidney function decline trajectories in high-risk populations using both computational and genetic approaches. A machine learning study developed models to predict membership in high-risk longitudinal EGFR trajectories following acute kidney injury hospitalization, with the goal of identifying patients at risk of rapid progression toward kidney replacement therapy initiation. Separately, a large-scale European investigation examined the shared genetic architecture underlying both EGFR (estimated glomerular filtration rate) and albuminuria, two key chronic kidney disease indicators recognized by Kidney Disease: Improving Global Outcomes guidelines. While previous work has identified independent genetic loci associated with each trait individually, this study sought to elucidate common genetic markers of kidney function that operate both broadly across populations and specifically within type 2 diabetes patients, recognizing that chronic kidney disease represents a substantial global health and economic burden particularly among diabetic individuals.

Note: This section is necessarily brief because only 2 of your 14 provided abstracts actually concern serum eGFR; the other 12 focus on EGFR (epidermal growth factor receptor) in cancer research. If you intended to provide different publications for the EGFR wiki article, please share those abstracts and I can write a fuller synthesis.